Lotel LS Eye Gel 5 ml is a corticosteroid ophthalmic gel containing loteprednol etabonate (0.3% w/v) used to treat inflammation and pain in the eyes after surgery or due to allergy/infection. Its anti-inflammatory action effectively relieves post-operative discomfort and ocular swelling.
Key Features
| About Lotel LS 5 ml Eye Gel | |
|---|---|
| Drug Class | Corticosteroids, Ophthalmic Steroid |
| Subclass | Ophthalmic Steroid |
| Product Details | |
|---|---|
| Composition | Active ingredient:Â Loteprednol etabonate (0.3% w/v) Inactive ingredients:
|
| Packaging Type | Bottle |
| Pack Size | 5 ml |
| Dosage | Apply 1–2 drops in the affected eye, as directed by your physician |
| Therapeutic Class | Ophthalmic Anti-inflammatory |
| Action Class | Glucocorticoids |
| Chemical Class | Glucocorticoids |
| Manufacturer | Ajanta Pharma Ltd |
| Shelf Life | 2–3 years from the date of manufacturing |
| Usages | Treats post-operative inflammation and pain after ocular surgery, relieves swelling, itchiness, and redness due to infection or allergy |
| Country of Origin | India |
| Storage | Store at room temperature; use within 4 weeks of opening; discard if not used within this period |
How does Lotel LS Eye Gel work?
Loteprednol etabonate suppresses inflammatory mediators such as prostaglandins that cause pain, swelling, and redness in the eye. By binding corticosteroid receptors and inhibiting phospholipase A2, the drug quickly relieves inflammation and discomfort after surgery or during allergic/infective episodes.
- Suppresses production of prostaglandins and other mediators in the eye
- Inhibits inflammation, swelling, and redness
- Alleviates symptoms like itching, burning, and irritation
Mechanism of action:
- Binds to corticosteroid receptors for local action
- Inhibits phospholipase A2 to limit prostaglandin synthesis
Usage
- Reduces inflammation and pain after eye surgery
- Treats swelling, redness, and itchiness from allergies or infection
Dosage
Administer 1–2 drops as prescribed, starting typically 24 hours post-surgery, continuing for 2 weeks or per clinician’s direction.
Side Effects
- Eye irritation
- Blurred vision
- Eye pain
- Sensitivity to light
- Eye discharge
Interactions
- Other topical eye medicines may interact; inform your physician
- Rare systemic drug interactions due to low absorption
- Potential interactions with:
- Voriconazole
- Itraconazole
- Clarithromycin
- Smallpox vaccine
- Bromfenac
Pharmacokinetics
- Minimal systemic absorption after topical use; plasma levels undetectable
- Distributes mainly to blood cell components
- Slow hepatic metabolism
- Elimination mainly biliary/fecal as inactive form PJ-90; half-life ~2.8 hours
- Strong protein binding (~98%) limits side effects beyond the eye
Precautions
- Use only as prescribed
- Do not contaminate dropper tip
- Wear contact lenses only on doctor’s advice
- Monitor for signs of infection or worsening symptoms
Conclusion
Lotel LS Eye Gel 5 ml is a reliable corticosteroid for treating eye inflammation and pain post-surgery or due to allergy/infection. Strictly follow your doctor’s dosage and safety instructions for best results.
References
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7482125/
- https://pubchem.ncbi.nlm.nih.gov/compound/Loteprednol-Etabonate
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